Synthesis and Structure-Activity Relationships of Fenbufen Amide Analogs
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چکیده
منابع مشابه
Synthesis and structure-activity relationships of fenbufen amide analogs.
The previous discoveries of butyl fenbufen amide analogs with antitumor effects were further examined. The amide analogs with 1, 3, 4 and 8 carbons chains were prepared in 70-80% yield. Fenbufen had no cytotoxic effects at concentrations ranging from 10 to 100 μM. Methyl fenbufen amide had significant cytotoxic effects at a concentration of 100 μM. As the length of the alkyl amide side chain in...
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prepared by stirring a mixture of 1 with the corresponding carboxylic acid (1.1 equiv.) in the presence of dicyclohexylcarbodiimide (DCC) (1.1 equiv.) and 4-dimethylaminopyridine (DMAP) (0.1 equiv.) in CH2Cl2 at room temperature for 24 hours. The crude products, obtained after usual work up, were purified by preparative TLC on silica gel (Article No. 13794, E. Merck) using CHCl3 MeOH (9:1) as t...
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ژورنال
عنوان ژورنال: Molecules
سال: 2010
ISSN: 1420-3049
DOI: 10.3390/molecules15128796